PCOS patients served as their own controls for the ovulation and pregnancy rates. At the end of the CC cycles 4.2% of patients got pregnant and 65.2% of the remaining group got pregnant with metformin plus CC cycles (p=0.0001). We have not observed any serious side effects of metformin.
How long does it take to get pregnant on metformin?
There is some benefit starting about a month after beginning metformin. Metformin has a more substantial benefit for fertility when the woman has been taking it for at least 60 to 90 days.
How effective is metformin for fertility?
A Finnish study20 of 320 women who received metformin (1500–2000 mg/day) or placebo for 3 months prior to fertility treatment, and for a further 9 months during treatment and up to 12 weeks of gestation, demonstrated an increase in pregnancy rate from 40.4% to 53.6% (OR 1.61, 95% CI 1.13–2.29), with obese women …
Does metformin 500 mg help get pregnant?
Metformin can help improve your rate of ovulation, increasing your chances of getting pregnant. And metformin has benefits even after you get pregnant. It can reduce your risk of developing type 2 diabetes due to the blood sugar problems caused by PCOS.
Does metformin make you ovulate sooner?
A very recent report (Vandermolen et al., 2001) revealed that the use of metformin significantly increased the ovulation and pregnancy rates from CC treatment in anovulatory women with CC-resistant PCOS.
Can metformin cause twin pregnancy?
The additive effects of adjunctive treatments such as weight reduction, ovarian drilling, and clomiphene and metformin therapy may result in an increased incidence of higher-order multiple pregnancy and women need to be counseled about this risk.
Does Metformin help with implantation?
Ongoing pregnancy and implantation rates were significantly higher in women with a DS above 0.6647 who received metformin (56% and 33%) compared with those having a DS below 0.6647 with metformin (14% and 11%) and those having a DS above/below 0.6647 without metformin (20% and 7.1%/15% and 11%, respectively).