Frequent question: Is metformin approved for children?

Lifestyle interventions are pivotal. Metformin is the only oral medication approved for diabetes treatment in children. It has been studied in clinical trials in nondiabetic children and has been shown to have beneficial effects on body weight.

Is metformin FDA approved for children?

Metformin is US Food and Drug Administration (FDA) approved for use in children 10 years of age and older with T2DM and has been used off label to achieve weight loss in children.

Why would a child take metformin?

Metformin is the mainstay of treatment of type 2 diabetes in both children and adults, with effects mainly on improving insulin sensitivity and decreasing hepatic glucose output. Since 2000, there have been a large number of studies that have examined the use of metformin as a weight-loss drug in children with obesity.

Can a 11 year old take metformin?

Metformin should not be given to a child younger than 10 years old. Some forms of metformin are not approved for use by anyone younger than 18 years old.

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Which diabetic drugs are approved by the FDA for pediatric use?

Medication Summary

Among all of the noninsulin drugs currently in use to treat type 2 diabetes in adults, the US Food and Drug Administration (FDA) has approved metformin, liraglutide, and exenatide extended-release for use in children with type 2 DM.

What are the side effects of metformin?

Nausea, vomiting, stomach upset, diarrhea, weakness, or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away.

What labs should be monitored with metformin?

Drug-specific monitoring is also necessary (eg, serum creatinine and vitamin B12 in patients taking metformin, serum transaminases for patients taking a TZD).

What are the 3 mechanisms of action for metformin?

Metformin has been shown to act via both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms; by inhibition of mitochondrial respiration but also perhaps by inhibition of mitochondrial glycerophosphate dehydrogenase, and a mechanism involving the lysosome.

Is metformin good for PCOS?

Although usually used to treat type 2 diabetes, metformin can also help relieve insulin resistance in PCOS. It works by improving insulin sensitivity, which decreases glucose production in your body and increases peripheral glucose uptake and utilization.

How does metformin work in the body?

Metformin works by reducing the amount of sugar your liver releases into your blood. It also makes your body respond better to insulin. Insulin is the hormone that controls the level of sugar in your blood. It’s best to take metformin with a meal to reduce the side effects.

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How does metformin treat obesity?

This drug inhibits the enzymes responsible for the digestion of fat in the human gastrointestinal tract and prevents the absorption of fat in the digestive tract, thereby reducing calorie intake and weight control. Many studies support that metformin can promote weight loss in overweight or obesity patients.

Do pediatricians treat diabetes?

Your child’s long-term diabetes care likely will be handled by a doctor who specializes in metabolic disorders in children (pediatric endocrinologist). Your child’s health care team will also generally include a dietitian, a certified diabetes educator and a doctor who specializes in eye care (ophthalmologist).

What are the main drug for treatment pediatric type 2 diabetes mellitus and related co morbidities?


  • Hypoglycemic Agents.
  • Insulin. Metformin.

Is liraglutide approved for children?

[12/4/2020] ​The U.S. Food and Drug Administration has approved a supplemental indication for Saxenda (liraglutide) for chronic weight management among pediatric patients aged 12 and older who are obese, as defined by specific body mass index (BMI) cut-offs for age and sex that correspond to a BMI 30 kg/m2 or higher …