Metformin can cause serum vitamin B12 deficiency, but studies on the influence of its duration and dose are lacking. We investigated vitamin B12 deficiency in patients with type 2 diabetes using metformin, in conjunction with other related factors.
What deficiency does metformin cause?
Years of metformin use were associated with increased risk of B12 deficiency (odds ratio, B12 deficiency/year metformin use, 1.13; 95% confidence interval, 1.06–1.20). Anemia prevalence was higher in MET, but did not differ by B12 status.
Does metformin interfere with vitamin absorption?
Long-term therapy with metformin is known to reduce intestinal absorption of vitamin B12 and folate. one study reports a highly significant inverse correlation between the dose and duration of metformin treatment and reduced serum levels of vitamin B12, with 33% of study participants affected.
Should you take vitamin B12 if you take metformin?
No interactions were found between metformin and Vitamin B12.
What vitamins should not be taken with metformin?
Metformin therapy has been shown to deplete vitamin B12, and sometimes, but not always, folic acid as well. People taking metformin should supplement vitamin B12 and folic acid or ask their doctor to monitor folic acid and vitamin B12 levels.
What vitamins and minerals does metformin deplete?
Metformin has been shown to deplete essential Vitamin B12 and Folic Acid in patients with type 2 (non-insulin-dependent) diabetes. When B12 and Folic Acid are depleted, other complications arise, such as increases in homocysteine levels.
What can happen if your B12 is low?
B12 deficiency can cause a variety of symptoms, including fatigue, headaches, depression, pale or yellow skin, mental impairment, and pain and inflammation in the mouth and tongue. Many of the symptoms caused by low B12 levels are not specific to B12 deficiency, which can cause the condition to go undetected.
Why does a patient taking metformin need B12 and folic acid monitored every 1/2 years?
Low levels of vitamin B12 can cause serious and sometimes permanent neurological damage, as well as bone marrow production issues with subsequent anemia, and so it’s vital that levels of this nutrient be monitored in anyone who takes metformin (which is available as a generic product as well as under the brand names …
What is the best vitamin for a diabetic to take?
What are the best vitamins for people with diabetes?
- Thiamin (b1) Those with type 1 or type 2 diabetes are more likely to have lower blood levels of thiamin and usually suffer a higher risk of thiamin deficiency than people who don’t have diabetes. …
- Vitamin B12. …
- Vitamin D. …
- Magnesium. …
- Vitamin E. …
- Vitamin C.
Can metformin cause vitamin D deficiency?
Our results show that metformin doesn’t lead to vitamin D deficiency.
How much vitamin B12 should I take if I am on metformin?
Thus, annual injections of vit B12 (in a dose of 1 mg) given to every patient on long-term metformin therapy will be a more practical and cost-effective method. This method will ensure replenishment of vit B12 stores for at least 1 year. It will also obviate the need for annual screening of vit B12 levels.
How do you know if metformin is working?
Metformin does not instantly reduce blood sugar levels. The effects are usually noticeable within 48 hours of taking the medication, and the most significant effects take 4–5 days to occur. However, the timing depends on the person’s dosage.
Can I take a multivitamin while on metformin?
Interactions between your drugs
No interactions were found between Daily Multi-Vitamins with Minerals and metformin. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Does vitamin C affect metformin?
No interactions were found between metformin and Vitamin C. This does not necessarily mean no interactions exist. Always consult your healthcare provider.