Can diabetes cause high B12?

Increasing duration of diabetes was associated with higher serum Vitamin B12 levels.

Does diabetes affect B12?

Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus.

What causes extremely high B12 levels?

Usually, excess vitamin B12 is removed in the urine. Conditions that can increase B12 level include: Liver disease (such as cirrhosis or hepatitis) Myeloproliferative disorders (for example, polycythemia vera and chronic myelogenous leukemia)

What are the symptoms of high B12 levels?

High doses of vitamin B-12, such as those used to treat a deficiency, might cause:

  • Headache.
  • Nausea and vomiting.
  • Diarrhea.
  • Fatigue or weakness.
  • Tingling sensation in hands and feet.

How much vitamin B12 should a diabetic take?

In the US, it is currently believed that adults with type 2 diabetes that are over 50 should take 2.4 µg of synthetic vitamin B12 daily either in supplement form or in fortified food.

Should I be worried if my B12 is high?

Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. UL refers to the maximum daily dose of a vitamin unlikely to cause adverse side effects in the general population.

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Is High B12 level a problem?

Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin.

What does high B12 mean in blood test?

High levels of vitamin B-12 can be a sign of liver disease, certain types of leukemia, or diabetes. Vitamin B-12 deficiency is a common condition. Between 1.5 and 15 percent of Americans have low levels of vitamin B-12, according to the National Institutes of Health .

Is B12 level of 1500 too high?

There is no consensus on the definition of high or elevated B12. Previous studies have chosen a variety of levels to represent high or very high B12 (pmol/l) levels. Some examples include: 664.219; 5131; 700 (high) and 1500 (very high)11; and 601 (high) and 1000 (very high)10.

Can stress cause high B12 levels?

Those who have to deal with highly stressful situations or are in a serious crisis need more vitamin B12 than usual. These situations can be high mental or physical stress such as important exams or difficult tests.

How long does it take to get rid of excess B12?

Unlike most other vitamins, B12 is stored in substantial amounts, mainly in the liver, until it is needed by the body. If a person stops consuming the vitamin, the body’s stores of this vitamin usually take about 3 to 5 years to exhaust.

Should Type 2 diabetics take vitamin B12?

Patients with type-2 diabetes, taking metformin, should have their vitamin B12 levels assessed more regularly to avoid irreversible nerve damage, according to a new study presented at the Society for Endocrinology annual conference in Glasgow.

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Does metformin affect B12?

Long-term therapy with metformin is known to reduce intestinal absorption of vitamin B12 and folate. one study reports a highly significant inverse correlation between the dose and duration of metformin treatment and reduced serum levels of vitamin B12, with 33% of study participants affected.

Does metformin reduce vitamin B12?

The largest prospective placebo-controlled randomized trial to date evaluating vitamin B12 levels with metformin in type 2 diabetes showed that over 4.3 years, metformin reduced vitamin B12 concentration by 19%, increased homocysteine concentration by 5%, and was associated with an 11-fold increased risk in low vitamin …