Metformin can cause megaloblastic anemia, due to vitamin B12 deficiency; therefore, we would advise annual blood panels to be required by the prescribing physician for all patients undergoing treatment with metformin.
Does metformin cause hemolytic anemia?
Although hemolytic anemia is a rare adverse effect of metformin, the physician and pharmacist should be aware of this potentially serious side effect of the drug, particularly in a patient with G6PD deficiency.
What deficiency does metformin cause?
Metformin can cause serum vitamin B12 deficiency, but studies on the influence of its duration and dose are lacking. We investigated vitamin B12 deficiency in patients with type 2 diabetes using metformin, in conjunction with other related factors.
Does metformin lower hemoglobin?
medwireNews: Metformin consistently causes an early reduction in hemoglobin and increases the risk for moderate anemia in patients with type 2 diabetes, a MASTERMIND consortium analysis of two randomized controlled trials (RCTs) and a real-world study shows.
Does metformin affect iron?
Indeed, it has recently been found that metformin, increasing insulin sensitivity, may decrease intestinal iron absorption in patients with PCOS (2). Mounting evidence indicates that higher body iron stores are associated with an increased risk of other insulin-resistant disorders such as type 2 diabetes (3).
Can you take iron and metformin together?
No interactions were found between Iron Sulfate and metformin. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
What vitamins should not be taken with metformin?
Metformin therapy has been shown to deplete vitamin B12, and sometimes, but not always, folic acid as well. People taking metformin should supplement vitamin B12 and folic acid or ask their doctor to monitor folic acid and vitamin B12 levels.
Should you take vitamin B12 when taking metformin?
No interactions were found between metformin and Vitamin B12.
Should you take vitamin B12 if you take metformin?
Why Some Diabetes Patients Taking Metformin Need More Vitamin B12. Researchers say metformin could be reducing vitamin B12 levels in some people with diabetes. The number one most prescribed drug to treat people with type 2 diabetes may actually be causing irreversible nerve damage in many patients.
Can metformin cause low red blood cells?
And some medications used to treat diabetes can drop your levels of the protein hemoglobin, which you need to carry oxygen through your blood. These drugs include ACE inhibitors, fibrates, metformin, and thiazolidinediones. If you take one of these, talk to your doctor about your risk for anemia.
Does metformin affect red blood cells?
Also, the erythrocytes (RBCs) count revealed a significant decrease in patients treated with metformin plus insulin. The decrease in RBCs counts in diabetic patients may be due to RBC membrane protein alterations, a decrease in hemoglobin levels and erythropoietin deficiency (13).
Patients with type 2 diabetes mellitus are twice more likely to be prone to anemia than the patients without diabetes. Bosman et al (2001) identified anemia as a risk factor for cardiovascular and end-stage renal diseases in diabetic patients .