The American Diabetes Association/European Association for the Study of Diabetes recommend a sulfonylurea, meglitinide, pioglitazone, or dipeptidyl peptidase 4 (DPP-4) inhibitor when metformin cannot be used. They also recommend using a glucagon-like peptide-1 (GLP-1) agonist if weight loss is warranted.
How many people Cannot tolerate metformin?
For those who have type 2 diabetes (T2D), the first drug given is typically metformin. But up to 15% of patients can’t tolerate it, and researchers have been looking for another low-cost first step for treatment.
How do I overcome the side effects of metformin?
Here are three tips for managing long-term metformin side effects:
- 1) Take your metformin with a meal. You’re less likely to experience problems if there’s food in your stomach. …
- 2) Switch to extended-release (ER) metformin. …
- 3) Be careful with dietary changes and supplements.
Is metformin making me sick?
Metformin does cause side effects in some people, but many of these are mild, and are associated with taking the medicine for the first time. Nausea and gastric distress such as stomach pain, gas, bloating, and diarrhea are somewhat common among people starting up on metformin.
Can you develop an intolerance to metformin?
Although it’s rare, metformin may cause allergic reactions. Signs of an allergic reaction include difficulty breathing, swelling of the face or hands, and a skin rash. You should seek immediate medical attention if you believe you’re experiencing an allergic reaction.
How long does it take to adjust to metformin?
Side effects often disappear or become less intense as the body adjusts to metformin, typically within about two weeks.
How long does it take for metformin side effects to go away?
It is common for many side effects to disappear or diminish in intensity as the patient’s body adjusts to the medication, but this is not always the case. While most side effects will dissipate in about two weeks, some patients experience troublesome side effects for much longer, including months or even years.