What is the rationale for the use of oral antihyperglycemic drugs in patients with type 2 diabetes?

What is the rationale behind multiple drug therapies used in the treatment of type II DM?

The idea is that combining in one pill drugs that have been proven, in controlled trials, to reduce cardiovascular events and mortality (aspirin, β-blockers, ACE inhibitors, and statins) may reduce the risk of recurrent vascular events.

What is the rationale for the use of oral antihyperglycemic drugs in a patient with type 2 diabetes?

Oral antihyperglycemic agents lower glucose levels in the blood. They are commonly used in the treatment of diabetes mellitus.

Why would a type 2 DM patient need oral hypoglycemic agents?

Non-FDA approved indications of oral hypoglycemic drugs, such as metformin, are for the prevention of type 2 diabetes mellitus, treatment of gestational diabetes mellitus, treatment of polycystic ovary syndrome (PCOS) with menstrual irregularities, and prevention of ovarian hyperstimulation syndrome in PCOS patients …

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Why do some diabetics take medications orally?

Oral diabetes medicines (taken by mouth) help control blood sugar (glucose) levels in people whose bodies still produce some insulin, such as some people with type 2 diabetes. These medicines are prescribed along with regular exercise and changes in the diet.

What is the best oral medication for type 2 diabetes?

Metformin is a tried and tested medicine that has been used for many decades to treat type 2 diabetes, and is recommended by most experts as first-line therapy. It is affordable, safe, effective, and well tolerated by most people.

What is the drug Rybelsus?

RYBELSUS® is a prescription medicine used along with diet and exercise to improve blood sugar in adults with type 2 diabetes.

What Antihyperglycemic means?

: counteracting the accumulation of excess sugar in the blood : hypoglycemic sense 2 antihyperglycemic agents Because metformin is the only drug associated with weight loss, or at least weight neutrality, it has become the most widely prescribed single antihyperglycemic drug and is generally regarded as the best first- …

What do Meglitinides do?

The meglitinides are insulin secretagogues, stimulating the release of insulin from pancreatic beta cells in a manner similar to that of the sulfonylureas.

How do oral hypoglycemic medications work in the gastrointestinal GI tract?

They work by stimulating insulin release from the insulin secreting ß-cells located in the pancreas [10] and may slightly improve insulin resistance in peripheral target tissues (muscle, fat) [11].

When is the use of oral hypoglycemic agents indicated?

Oral hypoglycemic drugs are used only in the treatment of type 2 diabetes which is a disorder involving resistance to secreted insulin. Type 1 diabetes involves a lack of insulin and requires insulin for treatment.

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What is the role of oral antidiabetic agents in the therapy for patients with diabetes?

These main classes include agents that stimulate insulin secretion (sulphonylureas and rapid-acting secretagogues), reduce hepatic glucose production (biguanides), delay digestion and absorption of intestinal carbohydrate (alpha-glucosidase inhibitors) or improve insulin action (thiazolidinediones).

How do oral hypoglycemic medications work in the body’s cells?

These oral hypoglycemic drugs exert their effects by activating so-called PPARγ (peroxisome proliferator-activated receptor-gamma) receptors, which are found primarily in adipose tissue; when activated, PPARγ prompts the transcription (synthesis of RNA from DNA) of genes that regulate glucose and lipid metabolism.

What is the purpose of oral medication?

PURPOSE: • Medications are administered orally to produce local effect on the alimentary canal or systemic effect after absorption into the blood stream. 10. Preparation of patient • Explain procedure to patient • Discuss need for medication • Assist client to sit if possible.

What are oral medications?

They come as solid tablets, capsules, chewable tablets or lozenges to be swallowed whole or sucked on, or as drinkable liquids such as drops, syrups or solutions. In most cases, the ingredients in oral medication don’t enter the bloodstream until they reach the stomach or bowel.

Which type of diabetes can be treated with oral agents and may or may not need insulin?

Most individuals with mild-to-moderate type 2 diabetes can manage the condition with oral medications or non-insulin injectable drugs, as well as lifestyle and dietary changes. Some people can even manage the condition with lifestyle changes alone.

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