What drugs can cause nephrogenic diabetes insipidus?

Causes of nephrogenic diabetes insipidus in adults include: Lithium, a drug most commonly taken for bipolar disorder; up to 20% of people taking lithium will develop nephrogenic diabetes insipidus. Other medicines, including demeclocycline (Declomycin), ofloxacin (Floxin), orlistat (alli, Xenical), and others.

What causes diabetes insipidus?

What causes diabetes insipidus? Diabetes insipidus is usually caused by problems with a hormone called vasopressin that helps your kidneys balance the amount of fluid in your body. Problems with a part of your brain that controls thirst can also cause diabetes insipidus.

Can antipsychotics cause diabetes insipidus?

Antipsychotic use has not been shown to be an independent risk factor for lithium-associated diabetes insipidus,2 despite the common coprescription of lithium and antipsychotics.

Does clozapine cause nephrogenic diabetes insipidus?

Common drug causes of NDI include lithium, foscarnet and clozapine. The exact mechanism by which olanzapine can cause DI is poorly understood, but may stem from a decrease in the expression of water channels (Aquaporin 2), alteration of which causes NDI.

Does phenytoin cause diabetes insipidus?

Drug-related central diabetes insipidus (Table ​1) It is known that phenytoin (diphenylhydantoin) and ethanol have a transient inhibitory effect on ADH release. Ethanol has also been suggested to cause NDI rather than CDI [34].

IT IS IMPORTANT:  Why do you lose a limb from diabetes?

Why does lithium cause nephrogenic diabetes insipidus?

Chronic lithium therapy can lead to accumulation in distal tubular cells causing impaired urinary concentrating ability. This can lead to partial or full nephrogenic diabetes insipidus. It is estimated to be present in up to 40% of patients on chronic lithium therapy [1].

How is diabetes insipidus prevented?

Your diabetes insipidus could be caused by kidney problems. If so, your doctor may recommend that you reduce salt in your diet. You’ll also need to drink enough water to avoid dehydration. Medicines like hydrochlorothiazide (a water pill) may also help.

What is the treatment for nephrogenic diabetes insipidus?

Treatment of Nephrogenic Diabetes Insipidus

Treatment consists of ensuring adequate free water intake; providing a low-salt, low-protein diet; and correcting the cause or stopping any likely nephrotoxin. Serious sequelae are rare if patients can drink at will.

Can risperidone cause diabetes insipidus?

However, hyperprolactinemia can be induced by risperidone, one of the atypical antipsychotics. Here, a case of drug induced nephrogenic diabetes insipidus and simultaneous hyperprolactinemia, which occurred in a patient with schizophrenia, is reported.

Can steroids cause diabetes insipidus?

Central diabetes insipidus is an uncommon, but life-threatening complication of pituitary apoplexy, most often emerging after steroid replacement.

Can Zyprexa cause diabetes insipidus?

Although olanzapine is considered to be a safe agent, there are several reports associating it with the development of hy- perglycemia, diabetes mellitus (3), and weight gain (4). To our knowledge, olanzapine has not been associated with the de- velopment of central or nephrogenic diabetes insipidus.

Why is Cabergoline prescribed?

Cabergoline is used to treat hyperprolactinemia (high levels of prolactin, a natural substance that helps breast-feeding women produce milk but can cause symptoms such as infertility, sexual problems, and bone loss in women who are not breast-feeding or men).

IT IS IMPORTANT:  Quick Answer: How do certain foods affect the glycemic index?

Which hormone does the nurse State has both inhibiting and releasing action?

Which hormone does the nurse state has both inhibiting and releasing action? Prolactin secreted by the hypothalamus has both inhibiting and releasing action.

What drugs cause Hypernatraemia?

Drug Induced Hypernatraemia

  • Diuretics.
  • Sodium bicarbonate.
  • Sodium chloride.
  • Corticosteroids.
  • Anabolic steroids.
  • Adrenocorticotrophic steroids.
  • Androgens.
  • Oestrogens.

Which drugs can cause hyponatremia?

Known offenders include acetazolamide, amiloride, amphotericin, aripiprazole, atovaquone, thiazide diuretics, amiodarone, basiliximab, angiotensin II receptor blockers, angiotensin-converting enzyme inhibitors, bromocriptine, carbamazepine, carboplatin, carvedilol, celecoxib, cyclophosphamide, clofibrate, desmopressin, …

Can lithium cause diabetes insipidus?

Lithium is the most common cause of acquired nephrogenic diabetes insipidus. It’s a medication often used to treat bipolar disorder. Long-term lithium use can damage the cells of the kidneys so they no longer respond to AVP.