What does it mean if my IGF 1 is low?

What do the results mean? If your child’s results show lower than normal levels of IGF-1, it probably means he or she has a GH deficiency or insensitivity to GH. In a child, this may be caused by a genetic disorder or brain disease. Your child may benefit from treatment with GH supplementation.

What causes low IGF levels?

Causes and Risk Factors

A lack of growth hormone is usually caused by damage to the pituitary gland or the hypothalamus, a part of the brain that controls the pituitary gland. The damage may be due to a tumor; to surgery or radiation used to treat the tumor; or to problems with the blood supply to the pituitary gland.

How can I increase my IGF-1 levels?

Conclusion: Supplementation with selenium and coenzyme Q10 over four years resulted in increased levels of IGF-1 and the postprandial IGFBP-1, and an increase in the age-corrected IGF-1 SD score, compared with placebo.

What affects IGF-1 levels?

Factors that are known to cause variation in the levels of growth hormone (GH) and IGF-1 in the circulation include: insulin levels, genetic make-up, the time of day, age, sex, exercise status, stress levels, nutrition level and body mass index (BMI), disease state, ethnicity, estrogen status and xenobiotic intake.

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What is the normal level of IGF-1?

The median serum IGF-I level was 374.1 ng/ml at the age of 18. The serum IGF-I level decreased to 180.1 ng/ml at the age of 35–39, which is 48.1% of that at age 18, and further decreased to 92.7 ng/ml at ages older than 70, which is approximately 24.8% of that at age 18.


People may also misuse or abuse IGF-1. The side effects of IGF-1 may be similar to those of other growth hormones. These include overgrowth of body tissues, known as acromegaly, and damage to the joints, liver, and heart. IGF-1 can cause your blood glucose levels to drop.

Does IGF-1 increase growth hormone?

Conclusion—IGF-1 is an important growth hormone, mediating the protein anabolic and linear growth promoting effect of pituitary GH. It has a GH independent growth stimulating effect, which with respect to cartilage cells is possibly optimised by the synergistic action with GH.

Does IGF-1 make you lose weight?

IGF-1 alone won’t result in weight loss but can help in lean muscle development. However, incorporating IGF-1 alongside a balanced diet together with increased cardiovascular and resistance workouts will result in faster weight loss over time. IGF-1 is not promoted as a weight loss tool.

What are the benefits of IGF-1?


  • Muscle hypertrophy effects.
  • Conserves muscle in heifers.
  • Increase lean muscle mass.
  • Improve athletic performance.
  • Improve muscle recovery after workouts.
  • Reduce recovery time after injuries.
  • Boost muscle protein synthesis.
  • Reduce Body Fat.
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How can I increase my IGF-1 naturally?

Here are 11 evidence-based ways to increase human growth hormone (HGH) levels naturally.

  1. Lose body fat. …
  2. Fast intermittently. …
  3. Try an arginine supplement. …
  4. Reduce your sugar intake. …
  5. Don’t eat a lot before bedtime. …
  6. Take a GABA supplement. …
  7. Exercise at a high intensity. …
  8. Take beta-alanine and/or a sports drink around your workouts.

Does IGF-1 raise testosterone?

A relationship between GH, IGF-1 and testosterone has previously been demonstrated. Curiously, no significant correlation is demonstrated between serum IGF-1 and testosterone levels or between testosterone levels and SHIM/EPIC scores in our work.

Does IGF-1 inhibit growth hormone?

The hypothalamic growth hormone (GH)-releasing hormone (GHRH) promotes non-rapid eye movement sleep (NREMS). Insulin-like growth factor-1 (IGF-1) acts as a negative feedback in the somatotropic axis inhibiting GHRH and stimulating somatostatin.

Can IGF-1 cause diabetes?

IGF-I has an almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycemic response. Studies showed that low and high IGF-I levels are related to impaired glucose tolerance and to a higher risk of type 2 diabetes.

What does IGF-1 LC MS test for?

This test is used to assess growth disorders in symptomatic children and adults and to monitor response to therapy.

What is the IGF-1 blood test?

A somatomedin C test, also called an insulin-like growth factor-1 (or IGF-1) test, helps doctors evaluate whether a person is producing a normal amount of human growth hormone (hGH, or somatotropin).