Olanzapine can cause fatal outcome like diabetic ketoacidosis that may lead to death. Same authors reported 23 deaths among 289 cases of hyperglycemia. Similarly, Spivak et al reported a case where patient had higher blood sugar level but after discontinuation of olanzapine it became normal.
Does olanzapine raise your blood sugar?
Compared to other atypical antipsychotics, olanzapine is more likely to result in an increase in blood sugar, or glucose, levels. Average increases of up to 15 mg/dL were reported in clinical trials.
Which antipsychotic is safe in diabetes?
Atypical Antipsychotics That Have a Lower Risk for Diabetes
The best antipsychotics for diabetes may be conventional antipsychotics or the atypical antipsychotics aripiprazole and ziprasidone.
What medications should diabetics avoid?
The drugs that might not mix well with meglitinides include:
- Azole antifungals.
- Certain antibiotics, including rifampin and isoniazid.
- Some high blood pressure medicines, such as calcium channel blockers, beta-blockers, and thiazide diuretics.
- Nicotinic acid.
- Oral contraceptives.
Does olanzapine cause low blood sugar?
In the present case, however, olanzapine resulted in hypoglycemia, not hyperglycemia, and it may be that there is a common metabolic abnormality; namely, olanzapine-induced insulin resistance.
Who should not take olanzapine?
low levels of white blood cells. low levels of a type of white blood cell called neutrophils. suicidal thoughts. a type of movement disorder called parkinsonism.
Can olanzapine cause diabetes 1?
Olanzapine therapy, in association with multiple factors, may have caused the patient’s significant hyperglycemia, which may have precipitated or accelerated the onset of type 1A diabetes.
Why does olanzapine cause diabetes?
Generally, olanzapine-induced diabetes is attributed to weight gain caused by increased appetite through the effect on the feeding center via blocking of 5-HT2C receptor, leading to insulin resistance-mediated development of diabetes.
Which antipsychotic has the lowest risk of diabetes?
There are many studies that show, however, that the risk of diabetes is greater with certain atypical antipsychotics, such as olanzapine (Zyprexa) and clozapine (Clozaril), whereas ziprasidone (Geodon) and aripiprazole (Abilify) are associated with the lowest risk.
What are the side effects of olanzapine?
Olanzapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dizziness, feeling unsteady, or having trouble keeping your balance.
- unusual behavior.
- difficulty falling asleep or staying asleep.
- difficulty walking.
What is the safest diabetic medication?
Metformin is still the safest and most effective type 2 diabetes medication, said Bolen.
What is the best drug for diabetes?
Metformin is a tried and tested medicine that has been used for many decades to treat type 2 diabetes, and is recommended by most experts as first-line therapy. It is affordable, safe, effective, and well tolerated by most people. When metformin does not adequately control blood sugar, another medication must be added.
What’s the best diabetic medication?
There are several classes of medications used to treat type 2 diabetes. Metformin is generally the preferred initial medication for treating type 2 diabetes unless there’s a specific reason not to use it. Metformin is effective, safe, and inexpensive. It may reduce the risk of cardiovascular events.
Is olanzapine a good drug?
Olanzapine has an average rating of 5.9 out of 10 from a total of 840 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 33% reported a negative effect.
Does olanzapine cause brain damage?
When taken together, both olanzapine and illness relapse have an effect on brain structure. Unlike uncontrolled studies, our randomized double-blind placebo-controlled clinical trial design provides potential evidence for causation: olanzapine administration may cause a decrease in cortical thickness in humans.