Spironolactone alone is as effective as the combination of spironolactone and losartan on albuminuria reduction in type 2 diabetic patients and can be used alone as an effective drug for diabetic nephropathy.
Does spironolactone mess with blood sugar?
The blood glucose curves above fasting levels after glucose loading were unchanged during spironolactone treatment, whereas the area under the net insulin curve was higher after 6 months of treatment (163 +/- 103 mU X h/l) than before treatment (105 +/- 71 mU X h/l), indicating a small and transient insulin resistance.
Which diuretic is best for diabetics?
We conclude that Indapamide is safe and effective in lowering blood pressure and contributes to better control of blood glucose and lipid levels in diabetic and dyslipidemic patients, compared to standard diuretics.
Does spironolactone increase insulin?
Treatment with spironolactone could improve glucose homeostasis by restoring insulin secretion in subjects with metabolic syndrome.
Why should diabetics not take diuretics?
Basically, diuretics can affect glucose levels in the blood because they impair glucose metabolism. When the body cannot break down glucose as it should, the glucose level in the blood rises.
Does spironolactone lower insulin?
The insulin levels at 60 min during OGTT, homeostasis model assessment-insulin resistance and area under curve of insulin were significantly lowered in overweight women after 12 months of spironolactone and weight loss and no negative changes in insulin secretion and sensitivity were observed in PCOS women after …
Does spironolactone decrease insulin resistance?
Low-dose spironolactone ameliorates insulin resistance and suppresses elevated plasminogen activator inhibitor-1 during gestational testosterone exposure.
What medications should diabetics avoid?
The drugs that might not mix well with meglitinides include:
- Azole antifungals.
- Certain antibiotics, including rifampin and isoniazid.
- Some high blood pressure medicines, such as calcium channel blockers, beta-blockers, and thiazide diuretics.
- Nicotinic acid.
- Oral contraceptives.
Can a diabetic take diuretic?
Diuretics (water pills) work better than newer and more costly medicines in the treatment of high blood pressure and prevention of some forms of heart disease in people with type 2 diabetes, according to results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Which ACE inhibitor is best for diabetics?
Captopril is the only FDA-approved ACE inhibitor for diabetic nephropathy although other ACE inhibitors may be as effective. Several studies demonstrated that lisinopril is effective in the reducing urinary albumin excretion in diabetes.
What is the side effect of spironolactone?
Drowsiness, dizziness, lightheadedness, stomach upset, diarrhea, nausea, vomiting, or headache may occur. To minimize lightheadedness, get up slowly when rising from a seated or lying position. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Is HydroCHLOROthiazide good for diabetics?
While thiazide diuretics are still a recommended medication of hypertension therapy for type 2 diabetes, treatment with low-dose HCTZ should be attempted to evaluate the effectiveness and adverse metabolic effects.
Can you take diuretics with metformin?
Diuretics are used to lower blood pressure and may increase your blood sugar levels. Taking these drugs with metformin may interfere with the effectiveness of metformin.
Is HydroCHLOROthiazide safe for diabetes?
Current use of hydrochlorothiazide is limited to low doses due to the known risk of hyperglycemia and diabetes in patients. A recent study combined HCTZ with amiloride to neutralize potassium loss and therefore neutralize glucose changes in patients.