Treatment with antidepressant drugs can directly interfere with blood glucose levels or may interact with hypoglycemic agents. The treatment of depression in diabetic patients must take into account variations of glycemic levels at different times and a comparison of the available antidepressant agents is important.
Do antidepressants increase blood sugar?
Some antidepressants can cause blood sugar to spike to 500 mg/dL or more, a very dangerous level. While studies have identified these negative effects, research has also shown that some antidepressants can sometimes help diabetes.
Do antidepressants affect glucose?
Antidepressants, including SSRIs and tricyclic antidepressants, have been found to interfere with blood glucose metabolism, increasing the risk of hypoglycemic episodes. Several reports have implicated antidepressants, especially SSRIs, in the development of clinically relevant hypoglycemia in diabetic patients.
What antidepressant does not affect blood sugar?
The class of antidepressant drugs known as selective serotonin reuptake inhibitors (SSRIs), which includes Prozac (fluoxetine), does not increase sugar levels.
Can antidepressants trigger diabetes?
Twelve cohort studies examining the relationship between antidepressants and diabetes have been published since 2008. In general, these show an increased risk of diabetes in those taking antidepressants, with hazard ratios (HRs) up to 3.5.
What antidepressants are safe for diabetics?
In diabetic neuropathy without depression, the best choices among non-TCAs may include sertraline, citalopram, and perhaps, venlafaxine, since the TCAs appear to increase cravings and increase FBG levels.
Does serotonin lower blood sugar?
“Under normal conditions serotonin controls the release of insulin, the most important hormone in the regulation of blood glucose concentration of humans and animals”, explains Diego Walther.
Can Zoloft cause high blood sugar?
Long-term use of the following antidepressant medications is associated with an increased risk for diabetes: fluvoxamine (Luvox), mirtazapine (Remeron), paroxetine (Paxil) and sertraline (Zoloft).
Can paroxetine cause diabetes?
Paroxetine Linked to Highest Weight Gain
The study found a 4-fold increased risk for diabetes associated with the long-term use of paroxetine in daily doses above 20 mg/day, but not of fluoxetine, citalopram, or sertraline.
Does Zoloft cause insulin resistance?
Increased blood triglyceride levels during sertraline treatment in our study might have been due to increased insulin secretion and insulin’s anabolic effects. Furthermore, HISS-dependent insulin resistance might also have been responsible.
Can you take antidepressants with metformin?
But taking antidepressants was associated with a two- to threefold increase in risk. The increase was not seen, however, in people at high risk for diabetes who were taking both antidepressants and the blood-sugar-regulating drug glucophage (metformin).
Can you take Zoloft with diabetes?
Using sertraline together with insulin or certain other diabetes medications may increase the risk of hypoglycemia, or low blood sugar. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat.
Does Zoloft cause low blood sugar?
It has not been reported to cause hypoglycemia independently, but in this case, a nondiabetic patient experienced multiple episodes of hypoglycemia that resolved after discontinuation of sertraline.