Hypoglycemia is a very rare side effect of ACE inhibitors in patients without diabetes. The results of the present study indicate that patients without diabetes may experience ACE inhibitor-induced hypoglycemia, which responds to discontinuation of the medication as in our patient.
Does lisinopril cause hypoglycemia?
Diabetes: ACE inhibitors such as lisinopril may lead to hypoglycemia (low blood sugar levels) for people with diabetes.
What is the most common side effect of ACE inhibitors?
ACE inhibitors and bradykinin
ACE inhibitors block the breakdown of bradykinin, causing levels of this protein to rise and blood vessels to widen (vasodilation). Increased bradykinin levels are also responsible for the most common side effect of ACE inhibitor treatment; a dry cough.
Why are ACE inhibitors contraindicated in diabetes?
Aliskiren enhances the hyperkalemic and nephrotoxic effect of ACE inhibitors, and use of aliskiren with an ACE inhibitor is contraindicated in patients with diabetes. Sacubitril is contraindicated with ACE inhibitors due to the increased risk of angioedema.
Can Enalapril cause hypoglycemia?
However, use of the ACE inhibitor enalapril was associated with an increased risk of hypoglycemia (odds ratio, 2.4; 95% CI, 1.1 to 5.3) in sulfonylurea users, suggesting that analyzing the unintended side effects of a class of drugs can sometimes mask the adverse effects of individual drugs.
Do ACE inhibitors affect blood sugar?
An ACE inhibitor or ARB is a good choice for people with diabetes. Unlike some medicines, these don’t affect blood sugar levels.
Can blood pressure meds cause hypoglycemia?
Context: Beta-Blockers and angiotensin-converting enzyme (ACE) inhibitors are effective antihypertensive agents for patients with diabetes mellitus. However, beta-blockers attenuate some components of the autonomic response to hypoglycemia and could increase the risk of hypoglycemia.
Do ACE inhibitors cause hypokalemia?
Because they inhibit renal potassium excretion, ACE inhibitors can ameliorate some of the hypokalemia that can occur with use of thiazide or loop diuretics. Cough is the most common complaint with ACE inhibitors.
Who Cannot take ACE inhibitors?
The following are people who shouldn’t take ACE inhibitors:
- Pregnant women. …
- People with severe kidney failure. …
- People who have ever had a severe allergic reaction that caused their tongue and lips to swell, even if it was from a bee sting, should not take ACE inhibitors.
What should be avoided when taking ACE inhibitors?
So, people taking ACE inhibitors should avoid eating large amounts of foods high in potassium, such as bananas. Other foods high in potassium include avocados, beets, oranges and orange juice, potatoes, spinach, tomatoes and tomato sauce, as well as salt substitutes.
Should diabetics be on ACE inhibitors?
8 The National Kidney Foundation recommends an ACE inhibitor or ARB in normotensive patients with diabetes and an albumin level greater than 30 mg per g who are at high risk of CKD or progression.
Do ARBs cause hypoglycemia?
Overall hypoglycaemia was associated with the use of ARBs [ROR 2, 95% confidence interval (CI) 1, 3] and with the use of ADAs (ROR 32, 95% CI 27, 37). Moreover, the use of ARBs was associated with the use of ADAs (OR 7, 95% CI 6, 8).
What drugs mask hypoglycemia?
Beta-blockers can mask the symptoms of hypoglycemia, such as a rapid heartbeat and tremor because they block the effects of norepinephrine, which results in a slowing of your heart rate and a reduced tremor. Hunger, irritability, and confusion may be concealed as well.
Do ACE inhibitors cause low blood pressure?
Although ACE inhibitors help to protect the kidneys, it can also cause kidney failure in some people. Severe vomiting or diarrhea. If you have severe vomiting or diarrhea you may become dehydrated, which can lead to low blood pressure.
How do ACE inhibitors increase insulin sensitivity?
ACE inhibition improves whole-body insulin sensitivity by increasing peripheral glucose disposal and glucose uptake in skeletal muscle and heart (18).
Can glucagon cause hypoglycemia?
If so, abnormal glucagon secretion is involved in the pathogenesis of both hypoglycemia and hyperglycemia in diabetes.