Best answer: Is diabetes a heterogeneous disease?

Type 2 diabetes is a heterogeneous disease with large variation in the relative contributions of insulin resistance and beta cell dysfunction between subgroups and individuals. Some of these differences are reflected in the way people are diagnosed.

What type of disease is diabetes classified as?

Diabetes is a heterogeneous complex metabolic disorder characterized by elevated blood glucose concentration secondary to either resistance to the action of insulin, insufficient insulin secretion, or both [1 ]. The major clinical manifestation of the diabetic state is hyperglycemia.

Is Type 1 diabetes heterogeneous?

Type 1 diabetes mellitus is a heterogeneous disease with multiple different features, but two major pathways can be discerned with either insulin autoantibodies or glutamic acid decarboxylase autoantibodies as the first autoantibody indicating initiation of the autoimmune process.

What is heterogeneous metabolic disorder?

A heterogeneous medical condition or heterogeneous disease is a medical term referring to a medical condition with several etiologies (root causes), such as hepatitis or diabetes.

Is diabetes a complex condition?

Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between genetic, epigenetic and environmental factors. While the major environmental factors, diet and activity level, are well known, identification of the genetic factors has been a challenge.

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What are the four classifications of diabetes?

Types of diabetes

  • Type 1 diabetes. Type 1 diabetes is most commonly diagnosed in children and teenagers. …
  • Type 2 diabetes. Type 2 diabetes happens when your body stops responding to the insulin your pancreas makes. …
  • Gestational diabetes.

What are the 3 types of diabetes?

There are three main types of diabetes: type 1, type 2, and gestational diabetes (diabetes while pregnant).

  • Type 1 Diabetes. Type 1 diabetes is thought to be caused by an autoimmune reaction (the body attacks itself by mistake) that stops your body from making insulin. …
  • Type 2 Diabetes. …
  • Gestational Diabetes.

What is Type 2 diabetes pathophysiology?

The pathophysiology of type 2 diabetes mellitus is characterized by peripheral insulin resistance, impaired regulation of hepatic glucose production, and declining β-cell function, eventually leading toβ -cell failure.

What is the difference between type1 and type2 diabetes?

The main difference between the two types of diabetes is that type 1 diabetes is a genetic disorder that often shows up early in life, and type 2 is largely diet-related and develops over time. If you have type 1 diabetes, your immune system is attacking and destroying the insulin-producing cells in your pancreas.

What is the pathogenesis of type 2 diabetes?

The pathogenesis of type 2 diabetes ordinarily involves the development of insulin resistance associated with compensatory hyperinsulinemia, followed by progressive beta-cell impairment that results in decreasing insulin secretion and hyperglycemia.

Is type 2 diabetes heterogeneous?

Type 2 diabetes is a heterogeneous disease with large variation in the relative contributions of insulin resistance and beta cell dysfunction between subgroups and individuals. Some of these differences are reflected in the way people are diagnosed.

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What does heterogeneity mean?

Definition of heterogeneity

: the quality or state of consisting of dissimilar or diverse elements : the quality or state of being heterogeneous cultural heterogeneity.

What is homogeneous in?

1 : of the same or a similar kind or nature. 2 : of uniform structure or composition throughout a culturally homogeneous neighborhood.

Is diabetes recessive or dominant?

Autosomal dominant, early onset diabetes (known as maturity-onset diabetes of the young, MODY) has been revealed to be a genetically heterogeneous condition, with mutations in the glucokinase gene [19] and in genes for various transcription factors (hepatocyte nuclear factor (HNF)-1α [20], HNF-1β [21], HNF-4α [22], …

Is type 2 diabetes a complex trait?

Because they depend on multiple genetic factors as well as environment, obesity and type 2 diabetes are called “multifactorial” or “complex” diseases.

What is the difference between diabetes and diabetes mellitus?

Diabetes mellitus is more commonly known simply as diabetes. It’s when your pancreas doesn’t produce enough insulin to control the amount of glucose, or sugar, in your blood. Diabetes insipidus is a rare condition that has nothing to do with the pancreas or blood sugar.