Best answer: How many people Cannot tolerate metformin?

For those who have type 2 diabetes (T2D), the first drug given is typically metformin. But up to 15% of patients can’t tolerate it, and researchers have been looking for another low-cost first step for treatment.

What should I do if I can’t tolerate metformin?

The American Diabetes Association/European Association for the Study of Diabetes recommend a sulfonylurea, meglitinide, pioglitazone, or dipeptidyl peptidase 4 (DPP-4) inhibitor when metformin cannot be used. They also recommend using a glucagon-like peptide-1 (GLP-1) agonist if weight loss is warranted.

Do most people tolerate metformin?

Most people tolerate metformin well, but some experience gastrointestinal issues when starting the treatment. Increasing the dosage gradually can help prevent side effects. However, some people are unable to tolerate even low dosages of metformin.

Why do doctors no longer recommend metformin?

In May 2020, the Food and Drug Administration (FDA) recommended that some makers of metformin extended release remove some of their tablets from the U.S. market. This is because an unacceptable level of a probable carcinogen (cancer-causing agent) was found in some extended-release metformin tablets.

Can you become intolerant to metformin?

STOCKHOLM — Genetic variants and certain common medications that interfere with gut absorption of metformin may both be tied to severe intolerance of the drug, new research shows.

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Does metformin cause abdominal discomfort?

Metformin does cause side effects in some people, but many of these are mild, and are associated with taking the medicine for the first time. Nausea and gastric distress such as stomach pain, gas, bloating, and diarrhea are somewhat common among people starting up on metformin.

Why is metformin not lowering my blood sugar?

Metformin does not lower blood sugar levels instantly like insulin injections. It may take a few weeks or months for a doctor to be able to tell whether metformin is working. Certain medications, including insulin and a group of drugs called sulfonylureas, can reduce blood sugar levels much more rapidly.

Why is metformin the drug of choice?

The UKPDS results, including glycemic-lowering efficacy, the weight benefits, the low risk for hypoglycemia, and the reduction in macrovascular complications, led to metformin becoming the preferred first-line therapy for treatment of type 2 diabetes.

What is an alternative to metformin?

Another type of drug, called salicylate, works in a similar way to metformin and scientists think it could be a good alternative for people with type 2 diabetes who can’t take metformin. Salicylate is already used to treat other health problems, like pain and inflammation.

How long can you stay on metformin?

The American Diabetes Association (ADA) also recommends metformin for some patients with prediabetes. Generally, if you are prescribed metformin, you will be on it long term. That could be many decades, unless you experience complications or changes to your health that require you to stop taking it.

Why is metformin bad for you?

Metformin can cause a life-threatening condition called lactic acidosis. People who have lactic acidosis have a buildup of a substance called lactic acid in their blood and shouldn’t take metformin. This condition is very dangerous and often fatal.

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Is metformin making me sick?

Metformin side effects can include diarrhea, nausea, vomiting, and gas. Taking metformin on a schedule can help reduce side effects. Most metformin side effects are short-term, which is 2 weeks or less. See a healthcare provider if you have long-term side effects of metformin.