Best answer: Can topical steroid cause hyperglycemia?

It has been hypothesized that topical corticosteroids cause hyperglycemia through increasing alanine transport, thereby facilitating hepatic gluconeogenesis, increasing enzymatic activity, and causing a relative insulin resistance [2].

What are the side effects of taking topical steroids?


  • Itching.
  • Burning/stinging sensation.
  • Redness and dryness.
  • Atrophy (thinning of the skin)
  • Striae (stretch marks) in the armpit or groin.
  • Easy bruising and tearing of the skin.
  • Telangiectasia (enlarged blood vessels often called “spider veins”)

Does hydrocortisone cause hyperglycemia?

Hydrocortisone induces hyperglycemia and it is possible that continuous hydrocortisone infusion would reduce the fluctuations in blood glucose levels and that tight blood glucose control could be better achieved with this approach.

Do corticosteroids cause hypo or hyperglycemia?

Most inpatients given glucocorticoids at a dose at least equivalent to 40 mg/day for more than 2 days develop hyperglycemia [11]. It is well known that glucocorticoid therapy may provoke new-onset type 2 diabetes mellitus (T2DM) and invariably worsens hyperglycemia in patients with preexisting diabetes mellitus [10].

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Do topical steroids enter the bloodstream?

Even with topical steroids, some of the medicine gets through the skin and into the bloodstream. The amount is usually small and causes no problems unless strong topical steroids are used regularly on large areas of the skin. The main concern is with children who need frequent courses of strong topical steroids.

What happens if you use too much topical steroid?

With long-term use of topical steroid the skin may develop permanent stretch marks (striae), bruising, discolouration, or thin spidery blood vessels (telangiectasias). Topical steroids may trigger or worsen other skin disorders such as acne, rosacea and perioral dermatitis. Skin colour may change.

Can steroid cream affect blood sugar?

If you’re taking topical steroid creams or gels or inhaled steroids, they do not typically affect blood sugar levels.

Will steroids raise your blood sugar?

About steroids

Steroids can increase blood sugar levels in people who have diabetes. It can also increase blood sugar levels in people who do not have diabetes. This can happen because: the liver produces more sugar during steroid treatment.

Can steroids bring on diabetes?

Long-term steroid usage can lead to insulin resistance. This is when the cells don’t respond to insulin anymore, and your blood sugar levels increase to a point that you are diagnosed with diabetes. This is steroid-induced diabetes. Sometimes taking steroids cannot be avoided.

Why do steroids cause diabetes?

Prednisone and other steroids can cause a spike in blood sugar levels by making the liver resistant to insulin. The pancreas produces insulin to control blood sugar levels. Diabetes can result from a fault in the way that the body reacts to insulin or a problem with the production of insulin in the pancreas.

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Can steroids cause hyperkalemia?

Corticosteroids cause hypokalemia, not hyperkalemia.

Does steroids increase blood sugar in Covid?


Steroids are medications used for treatment of several diseases, including COVID-19 [1,2]. While it is lifesaving in several individuals with COVID-19 infection (from moderate to severe), its pharmacological action increases blood glucose and poses additional challenges in the management.

Do topical steroids have systemic effects?

In addition to local side effects, prolonged use of topical steroids can cause systemic side effects which are less common than those due to systemic corticosteroids. These occur especially in infants and elderly patients.

Can topical steroids cause diarrhea?

If symptoms such as abdominal pain, fever or unusual digestive problems (diarrhea, constipation) occur during corticosteroid therapy, notify your physician. We know that these gastro-intestinal symptoms can encourage you to disrupt your treatment.

Can topical hydrocortisone raise blood pressure?

001) and -1.48 [-4.06; 0.29] μmol/mol creatinine (P < . 001) respectively. Conclusions: A higher dose of hydrocortisone increased systolic and diastolic BP and was accompanied by changes in the renin-angiotensin-aldosterone system, 11β-hydroxysteroid dehydrogenase enzyme activity, and circulating normetanephrine.